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Edaravone-encapsulated agonistic micelles rescue ischemic brain tissue by tuning blood-brain barrier permeability

2+ overload and collapse of the mitochondrial function which activates Ca 2+ -dependant proteases (Zorov et al., 2014

The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease

To advance clinical translation, we recommend prioritized efforts in three interrelated areas: (i) standardized, reproducible formulation and dose-finding studies integrating pharmacokinetics and pharmacodynamics (PK/PD)