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Patients were followed for 6 months with clinical, biochemical, endoscopic and intestinal ultrasound outcomes

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or in patients with chronic bronchitis where treatment periods were lengthy (1224 weeks) at doses of 400600 mg/day where NAC reduced the risk of exacerbations and improves symptoms in patients with chronic bronchitis compared with placebo (11 trials, 2,011 participants).(7) Clinical trial evidence for the use of NAC as an antioxidant in influenza and other acute viral respiratory tract infections is limited and relate to isolated small clinical trials

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Regardless, the possibility that down-regulation of other redox-dependent genes or processes upon p53 stabilization, or in response to other conditions leading to cell cycle arrest, can promote GSH accumulation and inhibition of ferroptosis cannot be excluded