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CAR-T cells have a particular effect in treating solid tumors such as renal cell carcinoma, HER2 positive sarcoma, ovarian cancer (94), and colorectal cancer (95)

As TRAIL-expressing astrocytes have been previously demonstrated to induce T-cell apoptosis and downstream CNS inflammation, notably, the expression of this receptor was dependent on meningeal IFN expression from NK cells, and the microbiota was known to induce IFN expression from NK cells (Sanmarco et al., 2021)