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323,324 The influential role of ALOX12, ALOX15, and 12-HETE on diabetes progression is also correlated with NOX (nicotinamide adenine dinucleotide phosphate oxidase)-mediated endoplasmic reticulum stress, TRPV1 activity, and MAPK signaling, ultimately leading to cell apoptosis

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[142] reported that glucose-derived CDs successfully crossed the BBB transporting small molecular cargo in both murine and zebrafish models, providing evidence of in vivo BBB permeability [142]

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