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doi: 10.18632/oncotarget.17589 83 ChenYHMcGowanLDCiminoPJDahiyaSLeonardJRLeeDYet al

Other coenzymes, such as nicotine adenine dinucleotide (NAD), coenzyme Q and FAD transfer electrons or hydrogen atoms

NNMT inhibition increases cellular concentrations of both substrates that the enzyme would otherwise consume: SAM (the universal methyl donor) and nicotinamide (the NAD + salvage precursor)