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Similarly, in the PI3K/AKT/mTOR pathway, mutation/inactivation of PTEN resulting in activation of PI3K and its downstream targets AKT and mTOR [45]

doi: 10.1016/0304-4165(91)90224-5

NF-B has been suggested as a key player in exacerbating liver inflammation, as phosphorylated NF-B levels are also elevated in preclinical models of NASH (dela Pea et al., 2005