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Keywords: anticancer agents, oral cavity cancer, oral diseases, antimicrobial, hypolipidemic, biomedical, antihypertensive, antitumour, coconut oil, lauric acid Introduction and background Lauric acid (LA), also known as dodecanoic acid, a saturated fatty acid in coconut oil, is known for its potential health benefits and biomedical applications

Acknowledgements The authors appreciate and thank the efforts of the Center for the Development of Clinical Researches of the Educational and Therapeutic Research Complex of Birjand University of Medical Sciences

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However, our data suggest several potential paths forward: both Osimertinib and CP-24 sensitize GBM cells to temozolomide and radiotherapy, downregulate DNA repair pathways, and reduce PD-1 protein levels, raising the prospect of rational combinations with standard-of-care treatments and/or immune checkpoint blockade