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doi: 10.1007/s40263-015-0272-9 Summary Keywords polycystic ovary syndrome, nutrients, vitamins, minerals, bioactive compounds, metabolism Citation Zhang Y, Shi B, Tian Y, Xu S and Chang H (2026) Nutrients and bioactive compounds in polycystic ovary syndrome: updated insights into effects and underlying mechanisms

Bile acids as metabolic regulators and nutrient sensors

It is undergoing Phase III trials to evaluate its safety in treating DED caused by dry eye syndrome (NCT05310422 and NCT04819269)

However, while current findings are encouraging, more rigorous clinical trials are essential to confirm their efficacy, determine optimal dosages, and assess long-term safety profiles

A more reliable technique is to reduce (knockdown) expression of the gene product, which can be achieved with RNA interference therapies that use a cells own machinery for regulating protein expression or with antisense oligonucleotides (ASO)