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Buch SC, Nazar-Stewart V, Weissfeld JL, Romkes M

2015 Development of the third generation of FOXO4-based anti-senescence drugs: the FOXO4-DRI peptide

[PubMed: 23982356] (Discussion of FDA warning that acetaminophen may cause Stevens Johnson Syndrome [SJS] or toxic epidermal necrolysis [TEM], a review identifying at least 91 cases, some with no other exposures and others with a positive rechallenge)

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Furthermore, while biological agents targeting specific inflammatory pathways have demonstrated promising clinical outcomes, approximately 3050% of patients either fail to respond initially or develop neutralizing antibodies that diminish therapeutic effectiveness over time