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Arab J Urology

Beyond HLA-B27, other immune-related genes are implicated (for example, pathways involved in antigen processing and mucosal immunity), which helps explain why AS can cluster with intestinal inflammation

8 The approved dosage of subcutaneous givosiran is 2.5 mg / kg once monthly

The cDNA libraries were prepared using the High-Capacity cDNA Reverse Transcription Kit (Thermo Scientific, USA), and qRT-PCR was performed using Power SYBR Green PCR Master Mix (Life Technologies, USA) on a Quant Studio 5 real-time PCR machine (Life Technologies, USA) to determine relative fold changes in target gene expression