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On the other hand, elevated TBC1D15 expression to increase Rab7 hydrolysis reduced membrane contacts between LE/Lys and mitochondria to confer neuroprotective effects against neuronal injury induced by epileptic seizure [86]

doi: 10.1016/j.explore.2019.08.004 72 XieX.YangC.CuiQ.MaW.LiuJ.YaoQ.et al

doi: 10.1038/s41422-020-0379-5 23 WeinhuserIPereira-MartinsDAAlmeidaLYHilberinkJRSilveiraDRAQuekLet al

Finally, in future research, we plan to complement our findings with in vitro experiments and utilize gene editing technologies (such as CRISPR/Cas9) to regulate specific genes or construct transgenic mouse models, allowing for a more in-depth verification of the role of ferroptosis in the pathogenesis of BPH