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This problem not only hinders the interpretability of algorithms but may also result in negative consequences, such as algorithmic collusion or abuse of power

Moreover, type I IFN induces the upregulation of PD-L1 and IDO-1 in DCs, contributing to the suppression of T cell responses to tumors

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[1] [4] Published phase 2 trial data (Jastreboff et al., NEJM , 2023) reported dose ranges from 1 mg up to 12 mg weekly, with higher doses associated with greater weight loss but also increased rates of gastrointestinal side effects