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it also reduced the risk of death or worsening disease by 33% versus chemotherapy

This result is suggestive of the constitutive activation of LKB1/AMPK pathway in the livers of KO mice

10.1016/j.joim.2020.01.008 236 LaneD

The pentose phosphate pathway, by generating NADPH, plays a crucial role in replenishing reduced glutathione levels, safeguarding the cell from oxidative damage and ensuring cellular survival and function