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Beyond redox activity, the unique properties of some metal elements provide these DDSs with additional functionalities

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Moreover, despite recent findings of a guanine nucleotide exchange factor (GEF) and GAPs for the Rag GTPases and the requirement of vacuolar H + -ATPase (v-ATPase, a proton pump for lysosomal acidification) in mTORC1 activation (4145), the signaling mechanism from amino acids to a Rag GEF and/or GAP is still unknown