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Secreted frizzled-related proteins (SFRPs) are antagonists of this pathway that bind Wnts, downregulate their ability to bind and activate FZD receptors, and inhibit this pathway (73)

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DHAR catalyses the reduction of DHA to AsA using glutathione (GSH) as a hydrogen donor before the spontaneous hydrolysis of DHA to irreversibly form 2,3-diketogulonic acid