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Low vitamin B12 levels can contribute to mental health issues as it is critical to nerve health

Only an estimated 1%2% of oral B12 can be passively absorbed and therefore, high dosages of oral B12 are required to provide therapeutic benefit in cases where the receptor-mediated process malfunctions (Withey et al., 1963)

For nausea specifically, glycine has mild calming effects on the digestive system, but it does not match the established evidence base that pyridoxine has for nausea reduction

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reported a higher rate of postoperative knee motion loss compared with the control group (13.6% vs 4.6%