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EPO serves as a primary hormonal regulator that enhances the survival, proliferation, and differentiation of erythroid progenitors through the activation of JAK2/STAT5 signaling pathways

One attempt to better understand and clinically correlate some of the disparate findings described above is comparison of the total number of domains or symptoms produced by those who have had TBI with a comorbidity of posttraumatic stress disorder (PTSD), those with TBI without a PTSD comorbidity, and those with PTSD but with no history of TBI or concussion

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Indeed, it induces the synthesis of TNF-, IL-1 and IL-6 in human leukocytes, as well as in epidermal keratinocytes and fibroblasts, by activation of NF-B, p38 and MEK1 signaling pathways [149, 150]