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The most typical manifestation is impaired aerobic endurance exercise performance, with adolescent and female athletes being particularly prone to iron deficiency

Food Sci Technol Int (2011) 17(4):395402

Several reports revealed that synovial macrophage pyroptosis promotes OA inflammation in chondrocytes through cytokine secretion (e.g., IL-1, IL-18), EV release with bioactive molecules, and direct chondrocyte death induction, leading to cartilage damage and OA progression[39], [40], [41]

In addition, many diseases are considered undruggable using standard biomacromolecules

Although studied under different physiological conditions, RBPs identified to have oxidative stress induced posttranscriptional modifications similarly have known fundamental roles in cardiac cells also