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Circadian GLP-1 Secretion in mice is dependent on the intestinal microbiome for maintenance of diurnal metabolic homeostasis

The main additional side effects come from injection site reactions, which remain mild and transient for most users

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Freeman and Company, 2021

Although the exact mechanisms by which the coordinated actions of GLP-1 receptor agonism and NMDA receptor antagonism correct metabolic diseases await further elucidation, the extensive alterations in transcriptomic and proteomic responses within the hypothalamus, linked to glutamatergic signalling and synaptic plasticity, imply that the conjugate might elicit neurostructural changes in GLP-1-receptor-expressing neurons