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Tolerability (animal only): Reported as well tolerated in limited rodent studies an animal observation, not a human safety finding

212 Additionally, TFEB can drive mitochondrial biogenesis independently of PGC-1 by upregulating NRF1/2 and transcription factor A (TFAM), leading to increased mtDNA synthesis

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These items can contribute to inflammation, disrupt the gut microbiome, and directly damage the intestinal lining