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Treatment with pemetrexed continued until RECIST v1.1 (modified to follow a maximum of 10 target lesions and a maximum of 5 target lesions per organ)-defined progression of disease as determined by the investigator or unacceptable toxicity

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Here it helps to convert propinonyl-CoA to methylmalonyl-CoA

We are talking about approximately 6 pounds of additional fat loss over three months