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Two rules hold across all three rows

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Energy stress-mediated AMPK activation and the activation of the Nrf2 antioxidant pathway also play important roles in regulating ferroptosis, through which metformin could alleviate ferroptosis and vascular calcification in high-lipid model mice

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RAGopathies are a broader set of disorders resulting from mutations in the RAG GTPases, 426 such as mutations of RAGA in cataracts, 427 RAGC 428 in dilated cardiomyopathy, RAGD in kidney tubulopathy and cardiomyopathy 429,430 and RAGC in follicular lymphoma