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341 For instance, treatment with nerve growth factor (NGF) or brain-derived neurotrophic factor (BDNF) enhances neurite outgrowth and supports neuronal survival

In this study, adults that were either obese or overweight with one weight associated condition were randomized to get subcutaneous retatrutide at various doses or placebo for a period of 48 weeks

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For example, administration of 2.4 mg/week of semaglutide (instead of 1 mg used in diabetics) for 68 weeks leads to average losses of 15% of initial body weight, approximately double that in type 2 diabetics (Figure 5A)