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Because angiogenesis is a defining hallmark of tumor growth and metastatic progression, any therapeutic agent that enhances neovascularization could, in theory, facilitate tumor expansion and promote metastatic dissemination

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[DOI] [PubMed] [Google Scholar] 258.Comhair S.A.A., McDunn J., Bennett C., Fettig J., Erzurum S.C., Kalhan S.C