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Test on a Small Area of Skin Patch Test: Patch test should be done on skin before applying any Kojic Acid cream on the full face

This is an important safety distinction

While the comproportionation reaction is a well reported redox cycling chemical mechanism, in this instance the triad model does not require the additional comproportionation reaction to accurately replicate the experimental OCR profile, suggesting that the comproportionation reaction is not mechanistically integral to the production of ROS through a quinone-based redox cycle

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A double blind placebo controlled study of the effects of AOD9604 in overweight and obese subjects human rct Stier H, et al