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Studies show by inhibiting NNMT, the 5 amino compound prevents unnecessary methylation of nicotinamide, thus preserving NAD+ for energy metabolism

Effects of abasic sites and DNA single-strand breaks on prokaryotic RNA polymerases

Acta Crystallogr D 69:24682482 Toska J, Ho BT, Mekalanos JJ (2018) Exopolysaccharide protects Vibrio cholerae from exogenous attacks by the type 6 secretion system