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1ac) and MCDD (Fig

The key enzyme in this activation pathway is arsenic methyltransferase (AS3MT), which catalyzes the methylation of inorganic arsenic to form metabolites such as monomethylarsonous acid (MMA III ) and Dimethylarsinous acid (DMA III )

Further studies proved the combined effect of resveratrol and arsenic trioxide on drug resistant cells

The cells were lysed with an ice-cold lysis buffer containing: 10 mM HEPES pH 7.5 (Sigma-Aldrich #H4034), 150 mM NaCl (Sigma-Aldrich #71376), 50 mM NaF (Sigma-Aldrich #201154), 1 mM EDTA (Sigma-Aldrich # ED), 1 mM EGTA, 10 mM Na 4 P 2 O 7 (Sigma-Aldrich #P8010) PMSF, and protease inhibitor cocktail (Roche #11873580001)

Efforts to develop novel arsenic-based compounds has led to the synthesis of Arsenoplatin-1 ( 2 , Fig