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ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors

2df and related panels in ESM Fig

Additionally, these agents improve cerebral blood flow, reduce microbleeds and white matter lesions, and promote amyloid clearance through peroxisome proliferator-activated receptor gamma (PPAR-) activation, unlike Ang-II inhibiting AHMs, which may impair amyloid degradation 10,36,37