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Etiology Mutation Mutation Genetic mutations are errors in DNA that can cause protein misfolding and dysfunction

10.1016/j.bbalip.2012.01.013 50 IbbettP.MurinelloS.LoteryA

[55] N-Acetylcysteine in Clinical Trails The basic question underlying NAC clinical trials is whether the repletion of available thiol groups will normalize lymphocyte glutathione levels, minimize cytokine-induced viral proliferation, and stop the CD4+ cell depletion associated with glutathione deficiency