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When incubated with sodium selenite or selenomethionine, placental tissue and Swan-71, JEG-3, and BeWo trophoblast-like cells exhibited increased respiratory capacity ( SELENOH and sodium selenite treatment in murine hippocampal HT22 neuronal cells resulted in greater oxygen consumption compared to control cells ( SELENOH overexpression prevented a decrease in mitochondrial respiration following UVB-irradiation ( in vitro , a recent study in horses investigated the potential for dietary Se to enhance skeletal muscle mitochondrial respiration in vivo ( via a proprietary Se yeast blend ( Selenoproteins Many biological effects of Se are mediated by Se-containing proteins, also known as selenoproteins, which generally contain at least one selenocysteine (a Se-containing amino acid and the main biological form of Se) and often serve oxidoreductase functions

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[5] When B12 and folate deficiency coexist, B12 replacement should be started before or alongside folic acid (typically 5mg daily) to avoid worsening neurological symptoms

1997 Cold Spring Harbor Laboratory Press