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The peculiarity of ruthenium compounds suggests that the research methods used for investigating platinum-based drugs may not fully be applied in these agents, because the cytotoxic mechanisms of cisplatin and ruthenium are different

Previous reports have shown the reduction of aldehydes into alcohols using NADH as a hydride source 15 , NAD + into NADH using formate as a hydride source 16 , pyruvate into lactate using formate as a hydride source 17,18 , or ally alcohols into ketones 19