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Understanding the mechanisms through which HFD undermines ovarian physiology is critical, as they extend beyond simple caloric excess to involve complex metabolic, oxidative, and inflammatory pathways

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(More information) At pharmacologic doses, nicotinic acid improved lipid profiles of patients with a history of vascular disease yet failed to reduce recurrent cardiovascular events or mortality

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Therefore, vitamin D may exert a potential dual effect on the OS and hormone signaling pathways within the uterine fibroid E-P-OS network