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In LSS, the expression of the E3 ubiquitin ligase Smurf1 is markedly elevated, which promotes fibrosis and oxidative stress in LF cells, contributing to the progression of LSS by facilitating the ubiquitination and degradation of NRF2 [112]

Standard effect sizes (Hedges g) for individual studies were estimated

Further research is necessary to assess the therapeutic potential of NLRP3 inhibitors, particularly when combined with other medications

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