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The primary safety and efficacy outcomes are any intracranial hemorrhage and NIH Stroke Scale Score at 30 (4) h, and these will be analyzed using a novel utility approach to maximize efficient detection of the most promising TS23 dose(s)

However, the corresponding Phe22 residue in OsDHAR is located too far away from the H-site bound GSH (distance between the NH of Phe22 and S of GSH was 6.5 ) for an interaction to occur, even after the conformational change 20

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Selenium is necessary for the production of glutathione