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Surprisingly, we still detected an induction effect of DMF on most of the factors studied despite NRF2 silencing (Fig

Consistently, HIF1A also promotes GSH synthesis through transcriptional activation of GCLM and SLC7A11 , and pharmacological inhibition of SLC7A11 with erastin or sorafenib exacerbates cuproptosis 177,178

A plant-derived natural photosynthetic system for improving cell anabolism

Phosphorylated STAT3 can act as a transcription factor to regulate the production and secretion of cytokines, such as IL-6 and IL-10, resulting in immunosuppression

The internalization of iron by macrophages can modulate macrophage activity towards a pro-inflammatory phenotype, which may also depend on the pathway of iron intake