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These features harbor the potential to result in long tissue residency, enhanced potency, and longevity of cancer-specific immune responses

H.WilliamT.BoyleM

In addition, the increase of ROS could lead to lipid peroxidation of the cell membrane to produce a large amount of malondialdehyde (MDA), a product of oxidative stress

Beyond catalase, overexpression of thioredoxin-1 (TXN-1) in CAR-T cells restores redox balance and promotes a memory-like, metabolically persistent phenotype [244]