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Lokker N A, Mark M R, Luis E A, Bennett G L, Robbins K A, Baker J B and Godowski P J (1992) Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding

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Morrisons lab found that, in the case of melanoma, at least one mechanism that accounts for that inefficiency is the high level of oxidative stress the cells experience when circulating in the blood