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Typically, cytoplasmic and nuclear NAD(H) pools are more sensitive to changes in redox stress than the mitochondrial NAD(H) pool, which is stably maintained and required for cell survival under redox insults (108, 120)

Patients are advised to report any unexpected symptoms to their healthcare provider, and clinicians will typically monitor for symptoms of hypoglycemia or gastrointestinal upset during therapy

Doxorubicin analogues Doxorubicin (DOX) is a common topoisomerase II inhibitor widely used in the treatment of solid tumors and malignant hematologic diseases

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