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Kajarabille and Latunde-Dada 2019

Fong is going live to discuss this topic on her weekly Live with the Eczema Doc on Wednesday, January 8, at 12:30 PM PST

To test the effect of Sp in paraquat-induced oxidative stress model, seven days old wild type flies, constitutively expressing mitochondrial (mt)-roGFP, were exposed to 10 mM paraquat for 24 h and then co-treated with 2.5 mM Sp for 24 h, prior to roGFP fluorescence estimation

The redox potential for each of the two redox pairs is defined by the Nernst equation using the respective midpoint potential and ratios ( Q ) of oxidized to reduced roGFP and LA to DHLA, respectively (Equation 2)

As a pharmacologic therapeutic, optimizing the efficacy of GSH and minimizing its unintended effects means it is crucial to determine the correct timing, dose, and disease context (Hong et al., 2005)