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Children with severe deficiency can suffer from rickets, characterised by soft and weak bones

Lactate is a bridge linking glycolysis and autophagy through lactylation

In this study, we utilized the ultraviolet enzymatic method to measure serum GR activity in apparently healthy adults aged 20 to 79 years

GroverMCamilleriMHinesJBurtonDRyksMWadhwaAet al

Remarkably, Erastin highly increased OCR in LDHB KD (siLDHB + Erastin) but not in control A549 cells (siNT + Erastin) ( Figure 4d, Supplementary Figure 8c ), suggesting that cancer cells subjected to combined inhibition of LDHB and SLC7A11 undergo a high level of OXPHOS