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Hypoactivity is not present in Lurcher mice, since they have similar activity levels in the T-maze and open field compared to WT mice [121,122,123]

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Iron overload exacerbates insulin resistance and increases hepatic gluconeogenesis

Mitochondrial autophagy (mitophagy) is critical for the clearance of damaged mitochondria, and it is primarily regulated by two proteins, PTEN-induced putative kinase 1 (PINK1) and the E3 ubiquitin ligase Parkin

The high metabolic demands of malignant gliomas create a hypoxic tumor microenvironment (TME), triggering a shift in tissue metabolism towards glycolysis, which ultimately leads to elevated lactate levels [144]