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R 1 is methyl At least one of R 2 and R 3 is NH 2

NNMT inhibition with 5-Amino-1MQ reduced white adipose tissue mass by ~35% in diet-induced obese mouse models without suppressing food intake, suggesting energy expenditure modulation

Because AOD-9604 works peripherally on fat tissue through beta-3 adrenergic receptors without affecting central appetite pathways, there is no adaptation of hunger-regulating systems and therefore no rebound effect when stopping