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10.1038/ismej.2010.129 251 SenderR.FuchsS.MiloR

The hypermethylation of specific 5-C-phosphate-G-3 (CpG) dinucleotides is detected in CpG islands previously shown to affect OXTR gene expression in ASD individuals that are correlated with aberrant oxytocinergic signaling and social interaction deficits [86]

The trial endpoints include both traditional AD outcomes (e.g., cognition, brain imaging, AD fluid biomarkers) and gold standard aging measures (e.g., frailty, physical function, epigenetic age, etc.)