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Characterized by iron toxicity accumulation, phospholipid peroxidation and dysfunctional mitochondria, ferroptosis is intricately linked to the hepatic microenvironment, influencing and being influenced by factors such as iron homeostasis, glucose metabolism, lipid metabolism, amino acid metabolism, and the gut-liver axis

In parallel, tocopheryl glucoside, a stable, water-soluble derivative of vitamin E, contributes to sustained cellular antioxidant defense by promoting the regeneration of intracellular vitamin E 14

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In the reduced state, GSH can react with CYS within proteins to maintain their reduced forms or with reactive oxygen species to neutralise them

ScienceDirect , Takeo, et al