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The formulation vehicle matters less than the biological reality of trying to push a large peptide through oral tissues

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doi: 10.3899/jrheum.171315 16 WuXJeongYPoli de FrasSEasthausenIHoffmanKOromendiaCet al

The PGC-1 protein plays the role of the co-activator for transcriptional factors participating in ROS neutralization such as FOXO and Nrf2, and also upregulates Sirt3 (reviewed in [96])