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Promising OS and PFS data have been shown, especially in non-squamous taxane-nave NSCLC (n=42), with a median PFS of 6.4 months (95% CI, 4.5 to 10.5) and median OS of 16.3 months (95% CI, 11.5 to NR), compared to 3.5 months (95% CI, 2.7 to 5.3) and 11.2 months (95% CI, 8.3 to 13.7), respectively, in all NSCLC subtypes [87]

Because it plays such a central role in protecting cells from oxidative stressthe internal wear and tear caused by free radicalsit is often referred to as the body's master antioxidant

Catechol-O-methyl transferase (COMT) is an enzyme expressed at a higher level in leiomyoma as compared to the normal myometrium (Salama et al., 2006)

doi: 10.1038/cddis.2014.390 209