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Animal studies utilizing acute stress models have shown that in mice stress-induced BBB permeability reduces the pyridostigmine dose required to inhibit brain acetylcholinesterase by 50% to less than 1/100th of the usual dose used (Friedman et al, 1996)

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Seven out of 20 studies reported an overall high risk of bias, due to bias from the randomization process, bias due to missing outcome data, bias in measurement of the outcome, and bias in selection of the reported result

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