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STORM Therapeutic based in the UK, developed the first METTL3 small molecule inhibitor STM2457 for leukemia treatment and advanced it into Phase I clinical trials [67]

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It is also unlikely that the Fe-porphyrin-mediated scavenging role of H 2 would account for all effects seen when, for example, the localization of the production of OH and the diffusion of H 2 from outside the cells - as it is often applied exogenously - are considered