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For instance, in human coronary artery endothelial cells, selective inhibition of PKC- by RBX during simulated ischemiareperfusion significantly restored Akt activation, enhanced anti-apoptotic signaling (iNOS, p-BAD), and suppressed pro-apoptotic mediators (p-FOXO, cleaved PARP, and caspase-3), thereby attenuating endothelial injury and supporting cardiovascular protection in both diabetic and non-diabetic settings [171]

The hippocampus, critical for memory and learning, exhibits lower methylation in active enhancers during early developmental stages (post-conceptional week 17

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It is involved in systemic regulation, particularly in the vascular system, where it is produced by various types of NOS