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doi: 10.1016/j.molimm.2011.07.002 25

Results showed that SHBG significantly enhanced mitochondrial flexibility, as indicated by the upregulation of MFN-1, PARKIN, and PINK genes

doi: 10.1101/CSHPERSPECT.A026112 36 AbuetabhYWuHHChaiCAl YousefHPersadSSergiCMet al

Although superoxide anion and hydrogen peroxide are not particularly reactive they may synergize with specific factors, eg iron, generating potent free radicals such as hydroxyl radical, which may cause direct injury through alteration of vital cellular macromolecules (DNA, protein or lipids)